Basic Research Studies / Ongoing Pilot Projects There is a strong commitment within the Center to basic research regarding the underlying mechanisms of Alzheimer's Disease and related disorders, and how this may translate into effective treatment. The following basic research studies are underway: Beta-amyloid modulation role of BACE1 and BACE2 Modeling an anti-amyloid therapy for AD Neuronal activity-dependent secretion of A-beta and immediate early genes Nicastrin and gamma secretase in AD Synapse formation in vitro The roles of A-beta, tau, and synaptic loss in early AD Transynaptic cortical apoptosis mechanisms and therapy

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