Johns Hopkins Medicine

Alzheimer's Disease Research Center

Lee J. Martin, Ph.D.

Dr. Martin Photo

Neuropathology Core: Co-Investigator
Associated Investigator

Dr. Martin's major research interest is cell death signaling in neurological disease. He uses animal and cell models of human neurodegenerative disease and the techniques of molecular neuropathology / neurobiology to unravel the mechanisms of neurodegneration.


  • LaClair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque B-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol 2016; 132: 859-873.
  • Fayzullina S, Martin LJ. Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). PLoS One 2014; 9: e93329.
  • Martin LJ, Chang Q. Inhibitory synaptic regulation of motoneurons: A new target of disease mechanisms in amyotrophic lateral sclerosis. Mol Neurobiol 2012; 45: 30-42.
  • Chang Q, Martin LJ. Motorneuron subtypes show specificity in glycine receptor channel abnormalities in a transgenic mouse model of amyotrophic lateral sclerosis. Channels 2011; 5: 299-303.