Lee J. Martin, Ph.D.
Neuropathology Core: Co-Investigator
Dr. Martin's major research interest is cell death signaling in neurological disease. He uses animal and cell models of human neurodegenerative disease and the techniques of molecular neuropathology / neurobiology to unravel the mechanisms of neurodegneration.
- Martin LJ, Chang Q. DNA damage response and repair: DNA methylation and cell death in human neurons and experimental animal neurons are different. J Neuropathol Exp Neurol 2018; 77: 636-655.
- Martin LJ, Wong M. Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration. Mech Ageing Dev 2017; 161: 149-162.
- LaClair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque B-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol 2016; 132: 859-873.
- Fayzullina S, Martin LJ. Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). PLoS One 2014; 9: e93329.
- Martin LJ, Chang Q. Inhibitory synaptic regulation of motoneurons: A new target of disease mechanisms in amyotrophic lateral sclerosis. Mol Neurobiol 2012; 45: 30-42.