Johns Hopkins Medicine

Alzheimer's Disease Research Center

Lee J. Martin, Ph.D.

Dr. Martin Photo

Neuropathology Core: Co-Investigator
Associated Investigator

Dr. Martin's major research interest is cell death signaling in neurological disease. He uses animal and cell models of human neurodegenerative disease and the techniques of molecular neuropathology / neurobiology to unravel the mechanisms of neurodegneration.


  • Martin LJ, Chang Q. DNA damage response and repair: DNA methylation and cell death in human neurons and experimental animal neurons are different. J Neuropathol Exp Neurol 2018; 77: 636-655.
  • Martin LJ, Wong M. Enforced DNA repair enzymes rescue neurons from apoptosis induced by target deprivation and axotomy in mouse models of neurodegeneration. Mech Ageing Dev 2017; 161: 149-162.
  • LaClair K, Donde A, Ling J, Jeong Y, Chhabra R, Martin LJ, Wong PC. Depletion of TDP-43 decreases fibril and plaque B-amyloid and exacerbates neurodegeneration in an Alzheimer's mouse model. Acta Neuropathol 2016; 132: 859-873.
  • Fayzullina S, Martin LJ. Skeletal muscle DNA damage precedes spinal motor neuron DNA damage in a mouse model of Spinal Muscular Atrophy (SMA). PLoS One 2014; 9: e93329.
  • Martin LJ, Chang Q. Inhibitory synaptic regulation of motoneurons: A new target of disease mechanisms in amyotrophic lateral sclerosis. Mol Neurobiol 2012; 45: 30-42.