Donald Price, M.D.
ADRC Director Emeritus
Donald L. Price, M.D., is Professor of Pathology, Neurology, and Neuroscience at The Johns Hopkins University School of Medicine. He is a clinical neurologist-neuropathologist-neurobiologist, who has made major contributions to the understanding of a variety of human neurodegenerative diseases, particularly Alzheimer’s Disease, Parkinson’s Disease and Amyotrophic Lateral Sclerosis. He has a distinguished record of publications in several fields, including: the study of these neurodegenerative diseases; the development and analysis of animal models -- especially genetically engineered models of these disorders -- and the investigation of experimental therapeutic strategies that prepare the way for translation of basic science discoveries to treatments of humans with neurological illnesses.
Dr. Price is the author of more than 500 publications in scientific journals. He has been recognized by the international scientific and medical communities, as illustrated by his ranking among the top ten neuroscientists as authors of high impact papers in neuroscience during the “Decade of the Brain”, Science Watch (12:102, 2001) http://www.sciencewatch.com/jan-feb2001/sw_jan-feb2001_page1.htm. Dr Price has received numerous honors and awards, including: two Javits Neuroscience Investigator Merit Awards from the National Institute of Neurological Disorders and Stroke; a Leadership in Alzheimer’s Disease Award from the National Institute on Aging; the Potamkin Prize for Alzheimer’s Disease Research from the American Academy of Neurology; the Wartenberg Award from the American Academy of Neurology; and the Metropolitan Life Foundation Award. He is on the Board of Trustees of the Adler Foundation and The Grass Foundation, was President of the Society for Neuroscience (2000-2001), and is a member of The Institute of Medicine (National Academy of Sciences).
Cai H, Wang Y, McCarthy D, Wen H, Borchelt DR, Price DL, Wong PC: BACE1 is the major beta-secretase for generation of Abeta peptides by neurons. Nat. Neurosci. 4:233-234, 2001.
Wong PC, Cai H, Borchelt DR, Price, DL. Genetically engineered mouse models of neurodegenerative diseases. Nat. Neurosci., 5:633-639, 2002.
Subramaniam JR, Lyons E, Liu J, Bartinakas T, Rothstein J, Price DL, Cleveland DW, Gitlin JD and Wong PC: Mutant SOD1 causes motor neuron disease independent of CCS-mediated copper loading. Nat. Neurosci., 5:301-307, 2002.
Sheng J.G., Price D.L., and Koliatsos V.E: Disruption of corticocortical connections ameliorates amyloid burden in terminal fields in a transgenic model of Abeta amyloidosis. J Neurosci 22, 9794-9799, 2002.
Li T, Ma G, Cai H, Price DL, Wong PC: Nicastrin is required for assembly of presenilin/g-secretase complexes to mediate Notch Signaling, and processing and trafficking of ?-APP in mammals. J. of Neurosci. 23: 3272-3277, 2003.
Li W, Hoffman PN, Stirling W, Price DL, Lee MK: Axonal transport of human ?-synuclein slows with aging but is not affected by familial Parkinson’s disease-linked mutations. J Neurochem. 88: 401-410, 2004.
Ma G, Li T, Price DL, Wong PC. APH-1a is the principal mammalian APH-1 isoform present in ?-secretase complexes during embryonic development. J. Neurosci. 25(1)192-198, 2005.
Cai H, Lin X, Xie C, Laird FM, Lai C, Wen H, Chiang HC, Shim H, Farah MH, Hoke A, Price DL, Wong PC: Loss of ALS2 function is insufficient to trigger motor neuron degeneration in knock-out mice but predisposes neurons to oxidative stress. J Neurosci. 25(33), 7567-74, 2005.
Laird F, Cai H, Savonenko A, He K, Melnikova T, Wen H, Chiang H, Xu G, Borchelt D, Price D, Lee H, Wong P: BACE1, a Major Determinant of Selective Vulnerability of the Brain to Aß Amyloidogenesis, is Essential for Cognitive, Emotional and Synaptic Functions. J. Neurosci. 25(50),11693-709, 2005.
Martin LJ, Pan Y, Price AC, Sterling W, Copeland NG, Jenkins NA, Price DL, Lee MK: Parkinson’s Disease a-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J. Neurosci. 26(1), 41-50, 2006.
Vice Chairman for Research, Department of Pathology
Director, Division of Neuropathology
Primary Appointment in Pathology
Secondary Appointments in Neurology,
Neuroscience
Member, Graduate Program in Neuroscience
Member, Graduate Program in Pathobiology
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