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| Our Team | |
Lee J. Martin, Ph.D.
Co-Investigator Email Address: martinl@jhmi.edu Dr. Martin’s major research interest is cell death signaling in neurological disease. He uses animal and cell models of human neurodegenerative disease and the techniques of molecular neuropathology / neurobiology to unravel the mechanisms of neurodegneration, with the hope that this will lead to novel mechanism-based targets for therapy in human neurological disease. 
Laird F, Farah M, Ackerly S, Hoke A, Maragakis N, Rothstein J, Griffin J, Price DL, Martin LJ, Wong PC. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vasicular trafficking. J. Neurosci 2008; 28: 1997-2005. Riudavets MA, Iacono D, Resnick SN, O’Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC. Resistance to Alzheimer pathology is associated with hypertrophy in neurons. Neurobiol Aging 2007; 28: 1484-1492. Lai C, Xie C, McCormack S, Chiang H, Michalak M, Lin X, Chandran J, Shin M, Shimoji M, Cookson M, Huganir R, Rothstein J, Price DL, Wong PC, Martin LJ, Zhu J, Cai H. Amyotrophic lateral sclerosis-2-deficienty leads to neuronal degeneration in amytrophic lateral sclerosis through AMPA receptor trafficking. J Neurosci 2006; 26: 11798-11806.
Martin LJ, Pan Y, Price A, Sterling W, Copeland N, Jenkins N, Price DL, Lee MK. Parkinson’s disease alpha-synuclein transgenic mice develop neuronal mitochondrial degeneration and cell death. J Neurosci 2006; 26: 41-50.
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