Juan C. Troncoso is Professor of Pathology and Neurology, and Director of the Brain Resource Center at Johns Hopkins University School of Medicine. His research interests focus on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders, such as Alzheimer’s disease, Frontotemporal Dementia, Parkinson’s disease and Huntington’s disease. His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology, and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically-engineered mouse models and in vitro systems. In recent years, the work of Dr. Troncoso and his collaborators has focused predominantly on the asymptomatic and early stages of Alzheimer’s disease.

Oh ES, Savonenko AV, King JF, Fangmark Tucker S, Rudow GL, Xu G, Borchelt DR, Troncoso JC. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiology of Aging, in press.

Iacono D, O’Brien R, Resnick SM, Zonderman AB, Pletnikova O, Rudow G, An Y, West MJ, Crain B, Troncoso JC. Neuronal hypertrophy in asymptomatic Alzheimer disease. J Neuropathol Exp Neurol. 2008; 67:578-589.

Oh ES, Troncoso J, Fangmark Tucker S. Maximizing the potential of plasma amyloid-beta as a diagnostic biomarker for Alzheimer’s disease. Neuromolecular Med. 2008;10:195-207.

Troncoso J, Zonderman A, Resnick S, Crain B, Pletnikova O, O’Brien R. Effect of infarcts on dementia in the Baltimore Longitudinal Study of Aging. Ann Neurol, 2008;2: 168-176.

Tucker S, Borchelt D, Troncoso J. Limited clearance of pre-existing amyloid plaques after intracerebral injection of Abeta antibodies in two mouse models on Alzheimer disease. J Neuropathol Exp Neurol., 2008; 67: 30-40.

Rudow GL, O’Brien R, Savonenko AV, Resnick SM, Zonderman AB, Pletnikova O, Marsh L, Dawson TM, Crain BJ, West MJ, Troncoso, JC. Morphometry of the human substantia nigra in ageing and Parkinson's disease. Acta Neuropathol. 2008; 115:461-470.

Riudavets MA, Iacono D, Resnick SN, O’Brien R, Zonderman AB, Martin LJ, Rudow G, Pletnikova O, Troncoso JC. Resistance to Alzheimer pathology is associated with hypertrophy in neurons. Neurobiology of Aging, 2007; 28:1484-1492.

Spina S, Murrell JR, Huey ED, Wassermann EM, Pietrini P, Baraibar MA, Barbeito AG, Troncoso JC, Vidal R, Ghetti B, Grafman J. Clinicopathologic features of frontotemporal dementia with Progranulin sequence variation. Neurol. 2007; 68: 820-827.

Primary Appointment in Pathology
Secondary Appointment in Neurology