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| Our Team | |
Philip Wong, Ph.D.
Email Address: wong@jhmi.edu Philip Wong is Professor of Pathology at Johns Hopkins University School of Medicine. His research program is focused on understanding the molecular mechanisms of neurodegenerative disorders, such as Alzheimer’s Disease and Lou Gerhig’s Disease. With the identification of mutations in genes linked to these diseases, he has taken advantage of transgenic and gene-targeting strategies to reproduce features of the human disorder in mice. He uses these animal models to study disease mechanisms and to design and test therapeutic strategies. 
Savonenko A, Melnikova T, Laird F, Stewart K, Price D, Wong PC. Alteration of BACE-1-dependent NRG1/ErbB4 signaling and schizophrenia-like phenotypes in BACE-1 null mice. Proc Natl Acad Sci, 2008; 105: 5585-5590. Li T, Wen H, Brayton C, Laird FM, Ma G, Peng S, Placanica L, Wu TC, Crain BJ, Price DL, Eberhart CG, Wong PC. Moderate reduction of ?-secretase attenuates amyloid burden and limits mechanism-based liabilities. J Neurosci, 2007;27: 10849-10859. Li T, Wen H, Brayton C, Das P, Smithson LA, Faug A, Fan X, Crain BJ, Price DL, Golde TE, Eberhart CG, Wong PC. EGFR and notch pathways participate in the tumor suppressor function of ?-secretase. J Biol Chem 2007; 282: 32264-32273. Laird FM, Cai H, Savonenko AV, Farah MH, He K, Melnikova T, Wen H, Chiang HC, Xiu G, Koliatsos VE, Borchelt DR, Price DL, Lee HK, Wong PC. BACE1, a major determinant of selective vulnerability of the brain to amyloid-beta amyloidogenesis is essential Ma G, Li T, Price DL, Wong PC. Aph-1a is the principal mammalian Aph-1 isoform present in ?-secretase complexes during embryonic development. J Neurosci, 2005; 25:192-198. 
Primary Appointment in Pathology Member, Graduate Program in Pathobiology Member, Program in Cellular and Molecular Medicine |
