Dr. O'Brien's laboratory investigates the molecular mechanisms involved in the early phases of Alzheimer's disease. Dr. O'Brien is also interested in the interaction between vascular disease and Alzheimer's disease.

Moghekar A, Rao S, Li M, Ruben D, Mammen A, Tang X, O’Brien R. Large quantities of Abeta peptide are constitutively released during amyloid precursor protein metabolism in vivo and in vitro. J Biol Chem 2011; 286: 15989-15997.

Dolan D, Troncoso J, Resnick S, Crain B, Zonderman A, O’Brien R. Age, Alzheimer’s disease and dementia in the Baltimore Longitudinal Study of Aging. Brain 2010; 133: 2225-2231.

Dolan H, Crain B, Troncoso J, Resnick Zonderman A, O’Brien R. Atherosclerosis, dementia and Alzheimer disease in the Baltimore Longitudinal Study of Aging. Ann Neurol 2010; 68: 231-240.

Troncoso J, Zonderman A, Resnick S, Crain B, Pletnikova O, O’Brien R. Effect of infarcts on dementia in the Baltimore Longitudinal Study of Aging. Ann Neurol 2008; 64: 168-176.

Primary Appointment in Neurology