Johns Hopkins Medicine

Alzheimer's Disease Research Center

Juan Troncoso, M.D.

Juan Troncoso, M.D.

Neuropathology Core Leader


Juan Troncoso is Professor of Pathology and Director of the Brain Resource Center at Johns Hopkins University School of Medicine. His research interests focus on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders. His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology, and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically-engineered mouse models and in vitro systems.


  • Pletnikova O, Kageyama Y, Rudow GL, LaClair K, Albert M, Crain B, Tian J, Fowler D, Troncoso J. The spectrum of preclinical Alzheimer's pathology and its modulation by ApoE genotype. Neurobiol Aging 2018; 71: 72-80.
  • Henderson BW, Gentry EG, Rush T, Troncoso JC, Thambisetty M, Montine TJ, Herskowitz JH. Rho-associated protein kinase 1 (ROCK1) is increased in Alzheimer's disease and ROCK1 depletion reduces amyloid-β levels in brain. J Neurochem 2016; 138: 525-31.
  • Hoy CY, Troncoso JC, Knox D, Stark W, Eberhart CG. Beta-amyloid, phospho-tau and alpha-synuclien deposits similar to those in the brain are not identified in the eyes of Alzheimer's and Parkinson's disease patients. Brain Pathol 2014; 24: 25-32.
  • Iacono D, Resnick SM, O'Brien R, Zonderman AB, An Y, Pletnikova O, Rudow G, Crain B, Troncoso JC. Mild cognitive impairment and asymptomatic Alzheimer disease subjects: Equivalent beta-amyloid and tau loads with divergent cognitive outcomes. J Neuropathol Exp Neurol. 2014; 73: 295-304.


Primary Appointment in Pathology
Secondary Appointment in Neurology