Johns Hopkins Medicine

Alzheimer's Disease Research Center

Juan Troncoso, M.D.

Neuropathology Core Leader


Juan Troncoso is Professor of Pathology and Director of the Brain Resource Center at Johns Hopkins University School of Medicine. His research interests focus on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders. His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology, and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically-engineered mouse models and in vitro systems.


  • Riudavets MA, Bartoloni L, Troncoso JC, Pletnikova O, St George-Hyslop P, Schultz M, Sevlever G, Allegri RF. Familial Dementia With Frontotemporal Features Associated With M146V Presenilin-1 Mutation. Brain Pathol.2013; 23: 595-600.
  • Driscoll I, Troncoso J, Rudow G, Sojkova J, Pletnikova O, Zhou Y, Kraut M, Ferrucci L, Mathis C, Klunk W, O'Brien R, Davatsikos C, Wong D, Resnick S. Correspondence between in vivo (11) C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. ActaNeurpathol 2012; 124:823-831.
  • Airavaara M, Pletnikova O, Doyle M, Zhang Y, Troncoso J, Liu Q. Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem 2011; 286: 45093-45102.
  • Liu Y, Lee MK, James M, Price D, Borchelt D, Troncoso J, Oh E. Passive (amyloid beta) immunotherapy attenuates monoaminergic axonal degeneration in the APPswe/PS1dE9 mice. J Alzheimers Dis 2011; 23: 271-279.
  • Oh ES, Savonenko AV, King JF, Fangmark Tucker S, Rudow GL, Xu G, Borchelt DR, Troncoso JC. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiology of Aging, 2009; 30: 1238-1244.


Primary Appointment in Pathology
Secondary Appointment in Neurology