Juan Troncoso, M.D.
Neuropathology Core Leader
Juan Troncoso is Professor of Pathology and Director of the Brain Resource Center at Johns Hopkins University School of Medicine. His research interests focus on the neuropathology of normal aging and the pathology, pathogenesis and therapy of neurodegenerative disorders, such as Alzheimer's disease, Frontotemporal Dementia, Parkinson's disease and Huntington's disease. His research encompasses clinical-pathological correlations, morphological studies using unbiased stereology, and investigations of the pathogenesis of neurodegenerative disorders in relevant genetically-engineered mouse models and in vitro systems. In recent years, the work of Dr. Troncoso and his collaborators has focused predominantly on the asymptomatic and early stages of Alzheimer's disease.
- Driscoll I, Troncoso J, Rudow G, Sojkova J, Pletnikova O, Zhou Y, Kraut M, Ferrucci L, Mathis C, Klunk W, O'Brien R, Davatsikos C, Wong D, Resnick S. Correspondence between in vivo (11) C-PiB-PET amyloid imaging and postmortem, region-matched assessment of plaques. ActaNeurpathol 2012, Epub ahead of print.
- Airavaara M, Pletnikova O, Doyle M, Zhang Y, Troncoso J, Liu Q. Identification of novel GDNF isoforms and cis-antisense GDNFOS gene and their regulation in human middle temporal gyrus of Alzheimer disease. J Biol Chem 2011 Epub ahead of print.
- Liu Y, Lee MK, James M, Price D, Borchelt D, Troncoso J, Oh E. Passive (amyloid beta) immunotherapy attenuates monoaminergic axonal degeneration in the APPswe/PS1dE9 mice. J Alzheimers Dis 2010 epub
- Oh ES, Savonenko AV, King JF, Fangmark Tucker S, Rudow GL, Xu G, Borchelt DR, Troncoso JC. Amyloid precursor protein increases cortical neuron size in transgenic mice. Neurobiology of Aging, 2009; 30: 1238-1244.
Primary Appointment in Pathology
Secondary Appointment in Neurology