Philip Wong, Ph.D.
ADRC Associate Director
Philip Wong is Professor of Pathology at Johns Hopkins University School of Medicine. His research program is focused on understanding the molecular mechanisms of neurodegenerative disorders, such as Alzheimer's Disease and ALS. With the identification of mutations in genes linked to these diseases, he has taken advantage of transgenic and gene-targeting strategies to reproduce features of the human disorder in mice. He uses these animal models to study disease mechanisms and to design and test therapeutic strategies.
- Jeong Y, Ling J, Lin S, Donde A, Braunstein K, Majounie E, Traynor B, LaClair K, Lloyd T, Wong PC. TDP-43 cryptic exons are highly variable among cell types. Mol Neurodegener 2017; 12: 13.
- Li T, Braunstein KE, Zhang J, Lau A, Sibener L, Deeble C, Wong PC. The neuritic plaque facilitates pathological conversion of tau in an Alzheimer's disease mouse model. Nat Commun 2016; 7: 12082-12094.
- Wang H, Megill A, Wong PC, Kirkwood A, Lee HK. Postsynaptic target specific synaptic dysfunctions in the CA3 area of BACE1 knockout mice. PLoS One 2014; 17: e92279.
- LaClair KD, Manaye KF, Lee DL, Allard JS, Savonenko AV, Troncoso JC, Wong PC. Treatment with bexarotene, a compound that increases apolipoprotein-E, provides no cognitive benefit in mutant APP/PS1 mice. MolNeurodegener.2013; 8: 18-26.
- Farrah M, Pan B, Hoffman P, Ferraris D, Tsukamoto T, Nguyen T, Wong PC, Price DL, Slusher B, Griffin JW. Reduced BACE-1 activity enhances clearance of myelin debris and regeneration of axons in the injured peripheral nervous system. J Neurosci 2011; 31: 5744-5754.
Primary Appointment in Pathology