Johns Hopkins Medicine

Alzheimer's Disease Research Center

Paul Worley, M.D.

REC: Leader

Dr. Worley's research focuses on the molecular basis of learning and memory. He has cloned a set of immediate early genes (IEGs) that are rapidly transcribed in neurons involved with information processing, and that are essential for long term memory. Immediate early gene proteins can directly modify synapses and provide insight into the cellular mechanisms that support synapse-specific plasticity. One of Dr. Worley's projects involves the role of IEGs in the secretion of the amyloid beta protein (A-beta) and the impact on synaptic dysfunction in Alzheimer's disease.


  • Xiao MF, Xu D, Craig MT, Pelkey KA, Chien CC, Shi Y, Zhang J, Resnick S, Pletnikova O, Salmon D, Brewer J, Edland S, Wegiel J, Tycko B, Savonenko A, Reeves RH, Troncoso JC, McBain CJ, Galasko D, Worley PF. NPTX2 and cognitive dysfunction in Alzheimer's Disease. Elife 2017; 6: e23798.
  • Na Y, Park S, Lee C, Kim D, Park J, Sockanathan S, Huganir R, Worley PF. Real-time imaging reveals properties of glutamate-induced Arc/Arg 3.1 translation in neuronal dendrites. Neuron 2016; 91: 561-573.
  • Kouser M, Speed HE, Dewey CM, Reimers JM, Widman AJ, Gupta N, Lui S, Jaramillo TC, Bangash M, Xiao B, Worley PF, Powell CM. Loss of predominant Shank3 isoforms results in hippocampus-dependnent impairments in behavior and synaptic tramsmission. J Neurosci 2013; 33: 18448-18468.
  • Wu J, Petralia R, Kurushima H, Patel H, Jung M, Volk L, Chowdhury S, Shepherd J, Dehoff M, Li Y, Kuhl D, Huganir R, Price DL, Scannevin R, Troncoso J, Wong PC, Worley P. Arc/Arg3.1 regulates an endosomal pathway essential for activity-dependent B-amyloid generation. Cell 2011; 147: 615-628.
  • Penner M, Roth T, Chawla M, Hoang L, Roth E, Lubin F, Sweatt J, Worley P, Barnes C. Age-related changes in Arc transcription and DNA methylation within the hippocampus. Neurobiol Aging 2010; 32: 2198-210.


Primary Appointment in Neuroscience